Across TCGA cell cohorts, ADH1B mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADH1B-associated genes across cancer lineages are TMIGD1, CCL23, and OR4F4. Each is linked with ADH1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH1B-to-partner and partner-to-ADH1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH1B→partner) and Y-score (partner→ADH1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMIGD1 →	+0.088	+5.029	<.001	.006	3	1
LUNG_SCLC	CCL23 →	+0.158	+5.029	<.001	.006	3	1
LARGE_INTESTINE	OR4F4 →	+0.020	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TIFAB →	+0.007	+5.562	<.001	<.001	3	1
LARGE_INTESTINE	TBC1D3 →	+0.123	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

ADH1B survival (RNA) · tumor vs normal (RNA) · all ADH1B data types