ADAM21

Across TCGA cell cohorts, ADAM21 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM21-associated genes across cancer lineages are CLRN1, HTR3B, and MOS. Each is linked with ADAM21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM21-to-partner and partner-to-ADAM21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLRN1 grouped by ADAM21-low versus ADAM21-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM21→partner) and Y-score (partner→ADAM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLRN1 →	+0.033	+6.266	<.001	<.001	3	2
CNS	HTR3B →	+0.368	+4.981	<.001	.008	3	1
CNS	MOS →	+0.047	+4.981	<.001	.008	3	1
CNS	OR52N5 →	+0.006	+5.754	.002	.002	3	1
CNS	DEFB132 →	+0.443	+5.321	<.001	.005	3	1
CNS	KRTAP10-10 →	+0.033	+6.357	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

CLRN1 by ADAM21 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →