ADAM21

Across TCGA pan-cancer cohorts, ADAM21 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ADAM21’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADAM21 RNA is repressed in tumor relative to normal tissue. In most cancer types ADAM21 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where ADAM21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.293	<.001	12	view →
HNSC	All	II,III,IV	+0.208	<.001	10	view →
THCA	Male	All	−0.259	<.001	9	view →
LIHC	All	II,III,IV	+0.314	<.001	8	view →
BRCA	All	All	+0.287	<.001	6	view →
LUAD	All	All	+0.258	<.001	6	view →
LUSC	All	All	+0.302	<.001	5	view →
KICH	All	All	−0.252	<.001	5	view →
PRAD	All	All	+0.625	<.001	2	view →
CHOL	All	All	+0.245	.015	2	view →
READ	Female	All	−0.252	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ADAM21–KIRC

Open the KIRC breakdown →