ADAL

Across TCGA patient cohorts, ADAL mutation is significantly associated with the RNA expression of many other genes, with 1,905 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAL-associated genes across cancer lineages are MTCO3P41, H2AC3P, and RN7SL266P. Each is linked with ADAL in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAL-to-partner and partner-to-ADAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO3P41 grouped by ADAL-low versus ADAL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAL→partner) and Y-score (partner→ADAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTCO3P41 →	+0.193	+6.080	<.001	.002	3	3
HNSC	H2AC3P →	+0.096	+4.736	<.001	.007	3	2
HNSC	RN7SL266P →	+0.103	+5.468	<.001	.002	3	2
UCEC	RNU4-58P →	+0.214	+2.811	.002	.004	3	2
UCEC	USP12PY →	+0.030	+3.351	<.001	.004	3	2
UCEC	RNU6-120P →	+0.294	+3.249	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,905 associations by consensus.

MTCO3P41 by ADAL expression — SKCM

Explore this box plot interactively →