ADAL

Across TCGA pan-cancer cohorts, ADAL RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ADAL’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ADAL RNA is repressed in tumor relative to normal tissue. In most cancer types ADAL is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KIRP are the cancer types where ADAL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.355	<.001	11	view →
KIRC	Male	II,III,IV	−0.739	<.001	11	view →
KIRP	Male	All	−0.562	<.001	6	view →
LIHC	Male	All	+0.562	<.001	6	view →
COAD	All	All	−0.348	.002	6	view →
LUSC	All	All	+0.371	<.001	4	view →
KICH	All	All	−0.596	.002	3	view →
READ	All	All	−0.673	.003	2	view →
HNSC	All	III,IV	+0.373	.017	2	view →
CHOL	All	All	+0.586	.021	1	view →
LUAD	Female	II,III,IV	−0.270	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ADAL–THCA

Open the THCA breakdown →