ACSL4

Across TCGA patient cohorts, ACSL4 mutation is significantly associated with the RNA expression of many other genes, with 4,055 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSL4-associated genes across cancer lineages are IPO5P1, RNU6-709P, and MIR95. Each is linked with ACSL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSL4-to-partner and partner-to-ACSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IPO5P1 grouped by ACSL4-low versus ACSL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSL4→partner) and Y-score (partner→ACSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IPO5P1 →	+0.308	+1.684	.008	.002	3	2
CESC	RNU6-709P →	+0.150	+5.367	<.001	<.001	3	2
CESC	MIR95 →	+0.293	+2.967	<.001	.005	3	2
COAD	RPL32P21 →	+0.346	+3.061	<.001	.005	3	2
BRCA	HMGB3P23 →	+0.038	+4.317	<.001	.007	3	2
BRCA	MTND5P17 →	+0.027	+4.362	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,055 associations by consensus.

IPO5P1 by ACSL4 expression — UCEC

Explore this box plot interactively →