ACSL4

Across TCGA pan-cancer cohorts, ACSL4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ACSL4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ACSL4 RNA is repressed in tumor relative to normal tissue. In most cancer types ACSL4 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where ACSL4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACSL4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.526	<.001	12	view →
HNSC	Female	III,IV	+1.597	<.001	11	view →
LIHC	All	III,IV	+3.343	<.001	9	view →
COAD	Female	II,III,IV	+1.042	<.001	9	view →
LUSC	Female	II,III,IV	−1.868	<.001	8	view →
KICH	Female	All	−2.259	<.001	7	view →
STAD	All	II,III,IV	+0.836	<.001	7	view →
LUAD	Female	All	−0.728	<.001	7	view →
READ	All	II,III,IV	+1.607	.004	6	view →
BRCA	All	III,IV	−1.115	<.001	6	view →
BLCA	Male	IV	−0.650	<.001	4	view →
CHOL	All	All	+2.184	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ACSL4–KIRC

Open the KIRC breakdown →