ACSL4

Across TCGA pan-cancer cohorts, ACSL4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ACSL4 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ACSL4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ACSL4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and ACC show a favorable association.

SKCM, UVM, and KIRP are the cancer types where ACSL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.863	0.724	<.001	90	view →
UVM	DFS	Quartile	III,IV	0.170	0.903	<.001	73	view →
KIRP	DFS	Quartile	II,III,IV	0.299	0.994	.008	37	view →
DLBC	DFS	Median	All	0.629	1.000	.017	31	view →
ACC	DFS	Quartile	III,IV	0.619	0.183	.004	28	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
HNSC	DFS	Tertile	All	0.556	0.768	.006	17	view →
LUAD	DFS	Median	II,III,IV	0.421	0.609	.010	15	view →
THCA	OS	Tertile	All	0.889	1.000	.012	14	view →
LGG	OS	Median	All	0.932	0.840	.005	12	view →
LIHC	OS	Tertile	III,IV	0.581	0.786	.022	12	view →
SCLC	DFS	Median	III,IV	0.338	0.968	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ACSL4–SKCM (OS)

Open the SKCM breakdown →