Q-omics provides the consensus-scored HMGB3P23 profile across patient tissues and cancer cell-line models. HMGB3P23 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in KIRC. Additionally, HMGB3P23 RNA expression shows 9,015 significant gene co-expression associations, with the highest sampling consensus in COAD. Together, these results highlight KIRC, and COAD as cancer lineages where HMGB3P23 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes HMGB3P23 survival associations across molecular data types. HMGB3P23 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

HMGB3P23 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	13	KIRC (126)	view →

This table ranks reproducible HMGB3P23 RNA expression–survival associations across cancer types. High HMGB3P23 expression shows unfavorable associations in KIRC, UCEC, UCS, BLCA, SKCM and ACC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for HMGB3P23 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.443	0.650	<.001	126	view →
UCEC	DFS	Tertile	All	0.661	0.847	.002	78	view →
UCS	DFS	Tertile	All	0.134	0.530	.001	54	view →
BLCA	OS	Tertile	IV	0.130	0.599	.002	54	view →
SKCM	OS	Tertile	IV	0.179	0.755	<.001	39	view →
ACC	OS	Tertile	All	0.133	0.686	.004	36	view →

Pink = unfavorable, green = favorable. all 13 lineages →

HMGB3P23-KIRC (OS)

Kaplan–Meier survival curve for HMGB3P23 RNA expression in KIRC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with HMGB3P23 in patient tissues and cancer cell lines. In patient samples, HMGB3P23 shows the broadest associations at the RNA and protein expression levels, with COAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	9,015	COAD (4516)	view →
Function (RNA)	5,851	STAD (5541)	view →