HMGB3P23

Across TCGA pan-cancer cohorts, HMGB3P23 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated HMGB3P23 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HMGB3P23 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HMGB3P23 expression acts as an unfavorable survival marker.

KIRC, UCEC, and BLCA are the cancer types where HMGB3P23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.443	0.650	<.001	126	view →
UCEC	DFS	Tertile	All	0.661	0.847	.002	78	view →
BLCA	OS	Tertile	IV	0.130	0.599	.002	54	view →
UCS	DFS	Tertile	All	0.134	0.530	.001	54	view →
SKCM	OS	Tertile	IV	0.179	0.755	<.001	39	view →
ESCA	OS	Tertile	IV	0.095	0.512	.008	36	view →
HNSC	DFS	Tertile	III,IV	0.345	0.606	.007	36	view →
PAAD	OS	Tertile	All	0.140	0.590	<.001	36	view →
ACC	OS	Tertile	All	0.133	0.686	.004	36	view →
KIRP	OS	Tertile	III,IV	0.268	0.808	.012	27	view →
LIHC	DFS	Tertile	All	0.205	0.445	.001	27	view →
SARC	OS	Tertile	All	0.108	0.827	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

HMGB3P23–KIRC (OS)

Open the KIRC breakdown →