ABHD8

Across TCGA cell cohorts, ABHD8 mutation is significantly associated with the mutation status of many other genes, with 3,491 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ABHD8-associated genes across cancer lineages are ADGRE2, WDR24, and FBXL16. Each is linked with ABHD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABHD8-to-partner and partner-to-ABHD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGRE2 grouped by ABHD8-low versus ABHD8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD8→partner) and Y-score (partner→ABHD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADGRE2 →	+2.407	+2.886	.008	.008	1	2
BLOOD_Leukemia	WDR24 →	+3.360	+3.946	<.001	<.001	1	2
LARGE_INTESTINE	FBXL16 →	+4.799	+3.672	.002	.002	1	2
BLOOD_Leukemia	SMARCA4 →	+3.067	+5.259	<.001	<.001	1	2
LARGE_INTESTINE	INO80 →	+2.951	+3.793	<.001	<.001	1	2
BLOOD_Leukemia	KCNC1 →	+3.430	+3.313	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,491 associations by consensus.

ADGRE2 by ABHD8 expression — LARGE_INTESTINE

Explore this box plot interactively →