ABHD8

Across TCGA pan-cancer cohorts, ABHD8 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ABHD8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ABHD8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ABHD8 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

KIRP, LIHC, and HNSC are the cancer types where ABHD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABHD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.772	<.001	11	view →
LIHC	Female	All	+0.827	<.001	8	view →
HNSC	Male	III,IV	+0.928	<.001	7	view →
BRCA	All	All	+0.235	.009	6	view →
COAD	All	II,III,IV	−0.357	.014	5	view →
LUAD	All	All	−0.392	<.001	4	view →
KICH	All	All	−0.515	.001	3	view →
THCA	Male	II,III,IV	−0.359	<.001	3	view →
READ	Female	All	−1.283	.021	2	view →
UCEC	All	IV	+1.139	.030	2	view →
ESCA	All	All	+0.641	.016	2	view →
PRAD	All	All	−0.528	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ABHD8–KIRP

Open the KIRP breakdown →