ABCD4

Across TCGA cell cohorts, ABCD4 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCD4-associated genes across cancer lineages are TAAR1, KHDC3L, and RFPL3. Each is linked with ABCD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCD4-to-partner and partner-to-ABCD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR1 grouped by ABCD4-low versus ABCD4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCD4→partner) and Y-score (partner→ABCD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TAAR1 →	+0.084	+4.415	<.001	.007	3	1
SKIN	KHDC3L →	+0.023	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	RFPL3 →	+0.037	+2.925	<.001	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR4F4 →	+0.015	+3.103	<.001	.004	3	1
LARGE_INTESTINE	KRT73 →	+0.086	+3.518	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TAAR1 by ABCD4 expression — SKIN

Explore this box plot interactively →