ABCD4

Across TCGA pan-cancer cohorts, ABCD4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ABCD4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ABCD4 RNA is repressed in tumor relative to normal tissue. In most cancer types ABCD4 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, BRCA, and BLCA are the cancer types where ABCD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.868	<.001	10	view →
BRCA	Female	II,III,IV	−0.626	<.001	6	view →
BLCA	All	All	+0.465	.006	6	view →
CHOL	Male	All	+0.676	.002	4	view →
LUSC	All	II,III,IV	−0.358	.001	4	view →
LUAD	Male	All	−0.213	.013	3	view →
STAD	Male	II,III,IV	+0.617	.014	2	view →
HNSC	Female	All	+0.462	.033	2	view →
READ	Male	All	−0.459	.016	2	view →
KIRC	Female	All	+0.386	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ABCD4–KICH

Open the KICH breakdown →