ABCD4

Across TCGA pan-cancer cohorts, ABCD4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ABCD4 data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ABCD4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCD4 expression acts as an unfavorable survival marker, although some lineages such as PAAD and BRCA show a favorable association.

ACC, UVM, and PAAD are the cancer types where ABCD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.253	0.640	<.001	92	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	36	view →
PAAD	DFS	Quartile	All	0.556	0.350	.004	32	view →
BRCA	OS	Quartile	III,IV	0.936	0.755	.002	26	view →
LGG	DFS	Tertile	All	0.262	0.453	<.001	25	view →
THYM	DFS	Quartile	All	0.876	0.289	<.001	24	view →
COAD	OS	Tertile	II,III,IV	0.739	0.876	.023	22	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
CESC	DFS	Quartile	II,III,IV	0.476	0.828	.009	18	view →
PRAD	DFS	Quartile	All	0.713	0.874	.011	18	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	16	view →
LIHC	DFS	Tertile	All	0.274	0.473	.021	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ABCD4–ACC (DFS)

Open the ACC breakdown →