ABCC2

Across TCGA cell cohorts, ABCC2 mutation is significantly associated with the RNA expression of many other genes, with 717 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCC2-associated genes across cancer lineages are FOXE3, SULT6B1, and MYF6. Each is linked with ABCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCC2-to-partner and partner-to-ABCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXE3 grouped by ABCC2-low versus ABCC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC2→partner) and Y-score (partner→ABCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FOXE3 →	+0.092	+2.711	.003	.003	3	2
OVARY	SULT6B1 →	+0.069	+3.643	.001	.002	3	2
OESOPHAGUS	MYF6 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	OR4E1 →	+0.016	+4.906	<.001	.006	3	1
BLOOD_Leukemia	C9 →	+0.919	+4.038	<.001	.001	3	1
BLOOD_Leukemia	KERA →	+0.004	+3.381	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 717 associations by consensus.

FOXE3 by ABCC2 expression — LARGE_INTESTINE

Explore this box plot interactively →