ABCC2

Across TCGA pan-cancer cohorts, ABCC2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ABCC2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ABCC2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ABCC2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where ABCC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+1.747	<.001	11	view →
HNSC	All	III,IV	+0.590	<.001	11	view →
COAD	Male	II,III,IV	+1.288	<.001	10	view →
THCA	Male	III,IV	−0.204	<.001	9	view →
KICH	All	II,III,IV	−1.986	<.001	7	view →
BLCA	All	IV	−0.692	<.001	6	view →
LUAD	All	All	+0.920	<.001	5	view →
LUSC	Male	All	+0.714	.007	4	view →
CHOL	All	All	−2.707	.001	3	view →
LIHC	Male	All	+0.557	.012	3	view →
READ	All	All	+1.661	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ABCC2–KIRC

Open the KIRC breakdown →