ABCC2

Across TCGA pan-cancer cohorts, ABCC2 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated ABCC2 data layer compared with 11 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ABCC2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCC2 expression acts as an unfavorable survival marker, although some lineages such as THYM and SCLC show a favorable association.

LUAD, HNSC, and SKCM are the cancer types where ABCC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.599	0.729	<.001	119	view →
HNSC	DFS	Tertile	II,III,IV	0.558	0.816	<.001	71	view →
SKCM	OS	Median	All	0.256	0.405	<.001	61	view →
BRCA	OS	Quartile	All	0.880	0.953	<.001	61	view →
KIRP	DFS	Quartile	All	0.808	0.962	<.001	47	view →
MESO	DFS	Quartile	III,IV	0.178	0.732	.010	21	view →
KICH	OS	Tertile	III,IV	0.452	0.913	.026	11	view →
THYM	OS	Median	All	0.983	0.715	.005	9	view →
SCLC	DFS	Tertile	II,III,IV	0.910	0.152	.006	6	view →
READ	DFS	Tertile	IV	0.771	0.112	.038	6	view →
THCA	OS	Quartile	All	0.788	0.945	.008	5	view →
KIRC	DFS	Quartile	IV	0.693	0.378	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

ABCC2–LUAD (DFS)

Open the LUAD breakdown →