ABCC12

Across TCGA cell cohorts, ABCC12 mutation is significantly associated with the RNA expression of many other genes, with 799 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCC12-associated genes across cancer lineages are GZMK, CNPY1, and GJA10. Each is linked with ABCC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCC12-to-partner and partner-to-ABCC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by ABCC12-low versus ABCC12-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC12→partner) and Y-score (partner→ABCC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GZMK →	+0.004	+4.029	<.001	.007	3	2
LUNG_NSCLC_LUAD	CNPY1 →	+0.280	+3.604	<.001	.004	3	2
BLOOD_Leukemia	GJA10 →	+0.024	+2.799	<.001	.005	3	2
BLOOD_Leukemia	SPATA19 →	+0.010	+3.762	<.001	.007	3	2
LARGE_INTESTINE	DDHD1 →	+0.907	+2.628	<.001	.002	3	2
LARGE_INTESTINE	CGRRF1 →	+0.564	+2.628	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 799 associations by consensus.

GZMK by ABCC12 expression — PANCREAS

Explore this box plot interactively →