ABCC12

Across TCGA pan-cancer cohorts, ABCC12 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ABCC12’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where ABCC12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ABCC12 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

BRCA, LUSC, and LUAD are the cancer types where ABCC12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCC12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.255	.010	6	view →
LUSC	All	II,III,IV	−0.032	<.001	3	view →
LUAD	All	III,IV	−0.037	.021	2	view →
THCA	All	All	+0.032	.024	2	view →
UCEC	All	All	+0.024	.028	2	view →
ESCA	All	All	−0.222	.025	1	view →
LIHC	All	All	+0.034	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ABCC12–BRCA

Open the BRCA breakdown →