AADAT

Across TCGA patient cohorts, AADAT mutation is significantly associated with the RNA expression of many other genes, with 433 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AADAT-associated genes across cancer lineages are LARP1, UBXN6, and PRELID1. Each is linked with AADAT in more than 1 cancer types. Because this analysis shows association rather than direction, both AADAT-to-partner and partner-to-AADAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARP1 grouped by AADAT-low versus AADAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AADAT→partner) and Y-score (partner→AADAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LARP1 →	+0.522	+3.595	.007	.001	3	2
UCEC	UBXN6 →	+0.489	+3.606	.002	.001	3	2
UCEC	PRELID1 →	+0.472	+3.638	.006	.001	3	2
UCEC	THOP1 →	+0.664	+3.212	.001	.009	3	2
UCEC	CDC34 →	+0.590	+3.584	.001	.003	3	2
SKCM	CHCHD6 →	+1.130	+3.207	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 433 associations by consensus.

LARP1 by AADAT expression — UCEC

Explore this box plot interactively →