AADAT

Across TCGA pan-cancer cohorts, AADAT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated AADAT data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher AADAT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AADAT expression acts as an unfavorable survival marker, although some lineages such as COAD and KIRP show a favorable association.

MESO, UVM, and COAD are the cancer types where AADAT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.286	0.476	.005	58	view →
UVM	DFS	Quartile	All	0.337	0.831	.002	49	view →
COAD	DFS	Median	II,III,IV	0.574	0.356	.004	41	view →
KIRP	OS	Quartile	All	0.873	0.513	.011	32	view →
ACC	DFS	Tertile	II,III,IV	0.544	0.916	.009	23	view →
THCA	OS	Quartile	All	0.855	0.992	.008	23	view →
UCEC	OS	Median	III,IV	0.893	0.760	.005	20	view →
LUSC	DFS	Quartile	III,IV	0.236	0.935	<.001	19	view →
UCS	OS	Quartile	II,III,IV	0.824	0.398	.014	18	view →
ESCA	DFS	Tertile	III,IV	0.302	0.561	.009	18	view →
LGG	OS	Median	All	0.944	0.833	<.001	14	view →
PAAD	DFS	Quartile	All	0.651	0.351	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

AADAT–MESO (OS)

Open the MESO breakdown →