AADAT

Across TCGA pan-cancer cohorts, AADAT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of AADAT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AADAT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AADAT is over-expressed in tumor, although a few such as LIHC and KIRC show the opposite, repressed pattern.

COAD, LIHC, and KIRC are the cancer types where AADAT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AADAT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.336	<.001	11	view →
LIHC	Female	II,III,IV	−2.757	<.001	9	view →
KIRC	All	II,III,IV	−0.374	<.001	8	view →
THCA	All	All	−0.407	<.001	7	view →
UCEC	All	II,III,IV	+0.735	.006	6	view →
KIRP	Male	All	−0.726	<.001	6	view →
LUAD	All	II,III,IV	−0.497	.006	6	view →
KICH	All	All	−0.738	<.001	5	view →
CHOL	All	All	−2.505	<.001	3	view →
LUSC	All	II,III,IV	−0.605	.010	3	view →
ESCA	All	All	+0.828	.003	2	view →
PRAD	All	All	+0.741	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

AADAT–COAD

Open the COAD breakdown →