AADAT

Across TCGA patient cohorts, AADAT mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AADAT-associated genes across cancer lineages are Annexin-1, Rab11, and BRCA2. Each is linked with AADAT in more than 1 cancer types. Because this analysis shows association rather than direction, both AADAT-to-partner and partner-to-AADAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by AADAT-low versus AADAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AADAT→partner) and Y-score (partner→AADAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.737	+2.827	.007	.035	3	2
UCEC	Rab11 →	-0.175	-2.999	.021	.035	3	1
UCEC	BRCA2 →	-0.155	-2.989	.019	.035	3	1
UCEC	Caspase-8 →	-0.343	-3.321	.009	.010	3	1
UCEC	Tuberin →	+0.348	+2.817	.013	.036	2	1
UCEC	Cyclin-B1 →	+0.778	+3.321	.008	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Annexin-1 by AADAT expression — UCEC

Explore this box plot interactively →