AADAT

Across TCGA cell cohorts, AADAT mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AADAT-associated genes across cancer lineages are MSGN1, TAFA1, and C14orf180. Each is linked with AADAT in more than 1 cancer types. Because this analysis shows association rather than direction, both AADAT-to-partner and partner-to-AADAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by AADAT-low versus AADAT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AADAT→partner) and Y-score (partner→AADAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.176	+3.155	<.001	.008	3	1
CNS	PRM3 →	+0.178	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MSGN1 by AADAT expression — LARGE_INTESTINE

Explore this box plot interactively →