Q-omics provides the consensus-scored A2M-AS1 profile across patient tissues and cancer cell-line models. A2M-AS1 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in STAD. Among the 18 cancer types available for tumor–normal comparison, A2M-AS1 is differentially expressed in 12, with the highest sampling consensus in THCA. Additionally, A2M-AS1 RNA expression shows 19,498 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight STAD, THCA, and THYM as cancer lineages where A2M-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for A2M-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes A2M-AS1 survival associations across molecular data types. A2M-AS1 RNA expression shows survival associations in the most cancer types (28). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible A2M-AS1 RNA expression–survival associations across cancer types. High A2M-AS1 expression shows unfavorable associations in STAD, LAML and GBM, but favorable associations in PAAD, LUAD and HNSC. The STAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify STAD as the clearest survival context for A2M-AS1 RNA expression.
This table summarizes A2M-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for A2M-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. A2M-AS1 shows lower tumor expression in THCA, KICH, LUAD, COAD, LUSC and UCEC. The THCA box plot shows higher A2M-AS1 RNA expression in normal versus tumor tissue (log2 FC = −1.495, t-test p < 0.001).
This table shows molecular features associated with A2M-AS1 in patient tissues and cancer cell lines. In patient samples, A2M-AS1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
