A2M-AS1

Across TCGA pan-cancer cohorts, A2M-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of A2M-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where A2M-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types A2M-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where A2M-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in A2M-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.495	<.001	11	view →
KICH	Female	II,III,IV	−1.474	<.001	10	view →
LUAD	Female	III,IV	−0.982	<.001	9	view →
COAD	All	II,III,IV	−0.578	<.001	8	view →
LUSC	All	III,IV	−1.040	<.001	7	view →
UCEC	All	All	−1.716	<.001	6	view →
BRCA	All	III,IV	−0.901	<.001	6	view →
STAD	All	All	−0.891	.001	5	view →
LIHC	All	All	+0.244	.020	4	view →
BLCA	Male	IV	−2.150	.001	2	view →
READ	All	All	−1.276	.008	2	view →
PRAD	All	All	−0.487	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

A2M-AS1–THCA

Open the THCA breakdown →