A2M-AS1

Across TCGA pan-cancer cohorts, A2M-AS1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated A2M-AS1 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher A2M-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated A2M-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUAD show a favorable association.

STAD, PAAD, and LAML are the cancer types where A2M-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.601	0.740	.001	42	view →
PAAD	DFS	Tertile	All	0.416	0.251	.010	38	view →
LAML	DFS	Tertile	All	0.392	0.665	.001	38	view →
LUAD	OS	Median	II,III,IV	0.856	0.635	.002	28	view →
HNSC	DFS	Tertile	IV	0.746	0.557	.004	26	view →
GBM	OS	Tertile	All	0.190	0.365	.003	20	view →
OV	DFS	Median	IV	0.409	0.217	.004	18	view →
PRAD	DFS	Tertile	All	0.975	0.912	.003	18	view →
ACC	DFS	Tertile	IV	0.656	0.057	.024	15	view →
UCEC	DFS	Median	IV	0.655	0.294	.019	14	view →
LUSC	DFS	Median	All	0.805	0.709	.006	12	view →
LGG	OS	Tertile	All	0.810	0.914	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

A2M-AS1–STAD (OS)

Open the STAD breakdown →