Regulation of store-operated calcium entry

Across TCGA cell cohorts, RNA activity of the Regulation of store-operated calcium entry pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD84, ZNF737, and CASR, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD84 grouped by Regulation of store-operated calcium entry-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CD84 →	-0.613	-2.186	.008	<.001	3	9
OVARY	ZNF737 →	-0.200	-1.201	.003	.005	3	6
UPPER_AERODIGESTIVE_TRACT	CASR →	-0.223	-0.254	.005	.008	2	6
BONE	UBE2D2 →	+0.224	+1.290	.002	.001	3	5
BLOOD_Lymphoma	PRKAR2B →	-0.340	-1.735	<.001	.002	3	4
BREAST	SPG11 →	-0.269	-0.463	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD84 by Regulation of store-operated calcium entry activity — URINARY_TRACT

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