Regulation of store-operated calcium entry

Across TCGA cell cohorts, RNA activity of the Regulation of store-operated calcium entry pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R11, PDIA4, and CDH18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R11 grouped by Regulation of store-operated calcium entry-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PPP1R11 →	-0.690	-0.972	<.001	.002	3	4
LIVER	PDIA4 →	+1.273	+1.459	<.001	.004	3	4
LUNG_SCLC	CDH18 →	-2.416	-1.242	.001	.001	3	4
CNS	DHDH →	+0.341	+0.688	.002	.004	3	4
BREAST	GNAQ →	-0.548	-1.013	.008	<.001	3	3
LIVER	TRIM16L →	-3.531	-1.402	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R11 by Regulation of store-operated calcium entry activity — BREAST

Explore this box plot interactively →