Regulation of phosphatidylcholine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of phosphatidylcholine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPCAT1, PTPRT, and LETMD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphatidylcholine biosynthetic process activity versus LPCAT1 in COAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LPCAT1 →	+0.769	+0.110	<.001	<.001	3	5
BRCA	PTPRT →	-1.223	-0.084	.004	.003	3	5
HNSC	LETMD1 →	-0.315	-0.129	.002	.008	3	5
UCEC	NXNL2 →	-1.223	-0.189	<.001	<.001	3	4
UCEC	CCDC146 →	-0.888	-0.134	<.001	.001	3	4
UCEC	SPAG8 →	-0.810	-0.118	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001245 vs LPCAT1 — COAD

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