Positive regulation of neuron migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuron migration pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, RPL12_S38, and NCAPH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron migration activity versus SMC2 in HNSC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMC2 →	+0.392	+0.054	<.001	.007	3	7
PDAC	RPL12_S38 →	+0.504	+0.035	.002	<.001	3	6
PDAC	NCAPH →	+0.267	+0.042	.003	<.001	3	6
BRCA	DLGAP4_T915 →	+0.504	+0.026	.001	.003	3	6
HNSC	GTF3C5 →	+0.197	+0.046	<.001	.002	3	6
HNSC	SMC4 →	+0.368	+0.052	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001224 vs SMC2 — HNSC

Explore this scatter interactively →