Positive regulation of neuron migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNA, EIF4B, and ATP5F1B, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron migration activity versus FLNA in LUNG_NSCLC_LUSC (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FLNA →	+2.504	+0.338	.006	.009	2	12
BLOOD_Lymphoma	EIF4B →	-0.844	-0.171	.004	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	ATP5F1B →	-1.145	-0.226	<.001	.005	3	7
BLOOD_Lymphoma	RPL3 →	-0.729	-0.182	<.001	<.001	3	7
LUNG_NSCLC_LUAD	FRMD6 →	+1.649	+0.150	<.001	<.001	3	7
LUNG_NSCLC_LUAD	CMTM8 →	-1.251	-0.216	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001224 vs FLNA — LUNG_NSCLC_LUSC

Explore this scatter interactively →