Regulation of corticosteroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Regulation of corticosteroid hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPM1F, SLF2_S68, and CSNK2A2_S18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of corticosteroid hormone secretion activity versus PPM1F in CCRCC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPM1F →	+0.188	+0.057	.002	.002	3	5
BRCA	SLF2_S68 →	-0.472	-0.059	<.001	.001	3	4
LUAD	CSNK2A2_S18 →	+0.399	+0.067	<.001	<.001	3	4
LUAD	KNG1_S332 →	+0.647	+0.079	<.001	.001	3	4
LUAD	NID1 →	+0.351	+0.093	<.001	<.001	3	4
HNSC	PDCD10 →	-0.168	-0.063	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000846 vs PPM1F — CCRCC

Explore this scatter interactively →