Regulation of double-strand break repair

Across TCGA patient cohorts, RNA activity of the Regulation of double-strand break repair pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP36_S73, SETDB1_S1066, and TACC3_S71, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of double-strand break repair activity versus RRP36_S73 in UCEC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRP36_S73 →	+1.055	+0.090	<.001	<.001	3	8
GBM	SETDB1_S1066 →	+1.147	+0.063	<.001	.001	3	8
HNSC	TACC3_S71 →	+0.895	+0.065	<.001	.003	3	8
HNSC	TOP2A_S1247 →	+1.029	+0.065	<.001	<.001	3	8
BRCA	BUB1_S655 →	+0.813	+0.020	.002	.002	3	8
GBM	CDK1 →	+0.762	+0.044	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000779 vs RRP36_S73 — UCEC

Explore this scatter interactively →