Negative regulation of type B pancreatic cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of type B pancreatic cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WFS1, TCF7L2, and CAST, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type B pancreatic cell apoptotic process activity versus WFS1 in LARGE_INTESTINE (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WFS1 →	+1.867	+0.172	<.001	<.001	3	14
SOFT_TISSUE	TCF7L2 →	+1.114	+0.123	.001	<.001	3	10
LUNG_SCLC	CAST →	+1.437	+0.243	<.001	<.001	3	10
PANCREAS	MAN2B2 →	+0.931	+0.166	.002	.004	3	9
UPPER_AERODIGESTIVE_TRACT	PIGG →	+0.865	+0.085	.008	.004	2	9
BONE	PRAG1 →	+1.386	+0.118	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000675 vs WFS1 — LARGE_INTESTINE

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