Negative regulation of stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP5D1, OAS1, and PTCHD3P2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell proliferation activity versus PPP5D1 in LUAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PPP5D1 →	+0.185	+0.356	.003	.007	3	5
BRCA	OAS1 →	-0.776	-0.577	.005	.002	3	4
LUAD	PTCHD3P2 →	+0.480	+0.371	<.001	.003	3	4
GBM	LINC02664 →	+0.594	+0.233	.004	.002	3	4
UCEC	WDR88 →	+0.453	+0.169	<.001	.006	3	4
GBM	NFIB →	+0.611	+0.168	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000647 vs PPP5D1 — LUAD

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