Regulation of primary miRNA processing

Across TCGA cell cohorts, RNA activity of the Regulation of primary miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOS3, MCM6, and ASPM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOS3 grouped by Regulation of primary miRNA processing-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NOS3 →	+3.650	+1.672	.004	<.001	3	4
OVARY	MCM6 →	+0.639	+0.864	.007	.005	2	5
STOMACH	ASPM →	+1.256	+1.264	.006	.008	2	4
OVARY	RNFT2 →	+0.930	+0.910	<.001	.008	3	3
PANCREAS	COPS7B →	+0.565	+0.859	.001	.001	3	3
PANCREAS	ZNF143 →	+0.425	+0.934	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOS3 by Regulation of primary miRNA processing activity — BLOOD_Lymphoma

Explore this box plot interactively →