Positive regulation of miRNA metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of miRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHB2, ZFP36, and NLRP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of miRNA metabolic process activity versus EPHB2 in OVARY (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EPHB2 →	+1.747	+0.967	.002	.003	3	5
KIDNEY	ZFP36 →	-1.882	-1.985	.008	<.001	3	3
SOFT_TISSUE	NLRP3 →	+1.430	+1.135	.004	.006	3	3
SOFT_TISSUE	GPR176 →	+2.481	+1.186	.001	.003	3	3
SOFT_TISSUE	CCDC121 →	-0.719	-1.212	<.001	.003	2	4
BLOOD_Myeloma	WASF1 →	+1.319	+1.417	.009	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000630 vs EPHB2 — OVARY

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