"Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA patient cohorts, RNA activity of the "Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAE1, RBM39, and TRIM28_S697, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity versus SAE1 in HNSC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAE1 →	+0.320	+0.090	<.001	<.001	3	7
HNSC	RBM39 →	+0.114	+0.054	.002	.004	3	7
LUAD	TRIM28_S697 →	+1.018	+0.064	<.001	<.001	3	6
UCEC	DDX47 →	+0.420	+0.095	<.001	<.001	3	6
GBM	SF3B3 →	+0.240	+0.048	.001	.003	3	6
LUAD	TOP2A_S1247 →	+0.941	+0.058	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000622 vs SAE1 — HNSC

Explore this scatter interactively →