Regulation of platelet-derived growth factor receptor-beta signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB24, STIP1, and TRMT61B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet-derived growth factor receptor-beta signaling pathway activity versus ZBTB24 in URINARY_TRACT (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZBTB24 →	-0.589	-1.707	.004	.008	3	4
CNS	STIP1 →	-0.451	-0.816	.001	.002	3	4
BREAST	TRMT61B →	-0.762	-0.978	<.001	.006	3	3
CNS	WDR74 →	-0.930	-1.166	<.001	<.001	3	3
SKIN	RPA2 →	-0.470	-0.695	.002	.001	3	3
SKIN	ISCA2 →	+0.371	+0.897	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000586 vs ZBTB24 — URINARY_TRACT

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