Positive regulation of DNA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170, COG1, and THBS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA biosynthetic process activity versus CEP170 in UCEC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CEP170 →	+0.209	+0.046	.006	.003	2	8
UCEC	COG1 →	-0.209	-0.058	<.001	<.001	3	7
CCRCC	THBS2 →	+1.173	+0.032	<.001	<.001	3	6
LSCC	MAP1B →	+0.700	+0.040	.003	<.001	3	6
GBM	SRRT →	+0.222	+0.033	.009	.003	3	6
LUAD	TOP2A →	+0.795	+0.047	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000573 vs CEP170 — UCEC

Explore this scatter interactively →