Positive regulation of gastrulation

Across TCGA patient cohorts, RNA activity of the Positive regulation of gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMA3-AS1, SMPD3, and DACT3-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gastrulation activity versus PSMA3-AS1 in GBM (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSMA3-AS1 →	-0.446	-0.439	<.001	.002	3	4
OV	SMPD3 →	-0.632	-0.429	.009	.005	3	4
LSCC	DACT3-AS1 →	-0.153	-0.242	.002	.001	3	4
UCEC	HTR6 →	-0.495	-0.288	.003	.008	3	3
UCEC	ANKS4B →	-0.584	-0.253	.001	.008	3	3
GBM	CDKL1 →	-0.520	-0.493	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000543 vs PSMA3-AS1 — GBM

Explore this scatter interactively →