Positive regulation of gastrulation

Across TCGA patient cohorts, RNA activity of the Positive regulation of gastrulation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD74_S25, KTN1_S1313, and MBTD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gastrulation activity versus CD74_S25 in CCRCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CD74_S25 →	+1.124	+1.646	.001	<.001	3	3
OV	KTN1_S1313 →	-0.959	-0.412	<.001	.001	3	3
CCRCC	MBTD1 →	-0.684	-1.466	.002	<.001	3	3
BRCA	MLLT1_S359 →	+0.565	+0.037	.002	<.001	3	3
PDAC	NRBP2_S22 →	-0.645	-0.762	<.001	<.001	3	3
OV	GLE1_S88 →	+1.144	+0.654	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000543 vs CD74_S25 — CCRCC

Explore this scatter interactively →