Positive regulation of gastrulation

Across TCGA cell cohorts, RNA activity of the Positive regulation of gastrulation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAX2, ANXA6, and CERT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VAX2 grouped by Positive regulation of gastrulation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	VAX2 →	+0.297	+0.198	.005	.002	3	4
BLOOD_Lymphoma	ANXA6 →	+0.371	+0.184	<.001	<.001	3	4
BLOOD_Leukemia	CERT1 →	-0.217	-0.190	<.001	.004	3	4
CNS	RHOG →	-0.206	-0.234	<.001	<.001	3	4
LARGE_INTESTINE	ZNF547 →	+0.285	+0.208	.005	.001	3	4
BLOOD_Leukemia	MED13 →	+0.130	+0.180	.009	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VAX2 by Positive regulation of gastrulation activity — BLOOD_Lymphoma

Explore this box plot interactively →