Regulation of dendritic cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of dendritic cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLRC4, PIK3R5, and RABEP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic cell chemotaxis activity versus NLRC4 in BLOOD_Leukemia (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NLRC4 →	-0.651	-0.129	.004	.003	3	3
BLOOD_Lymphoma	PIK3R5 →	-1.552	-0.156	.005	.001	3	3
BLOOD_Leukemia	RABEP1 →	+0.598	+0.128	<.001	<.001	3	3
BLOOD_Leukemia	COX10 →	+0.454	+0.174	<.001	<.001	3	3
BLOOD_Leukemia	MAN2B1 →	-1.404	-0.169	<.001	<.001	3	3
BLOOD_Leukemia	C1QBP →	+0.605	+0.182	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000508 vs NLRC4 — BLOOD_Leukemia

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