Regulation of protein neddylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein neddylation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATXN7L3B, THEM6, and C16orf91, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein neddylation activity versus ATXN7L3B in LSCC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ATXN7L3B →	-0.351	-0.105	.002	.001	2	5
CCRCC	THEM6 →	-0.350	-0.114	.008	.003	3	4
LUAD	C16orf91 →	-0.487	-0.091	<.001	.002	2	4
LUAD	MRPS34 →	-0.335	-0.078	.002	.008	3	3
BRCA	TMEM176B →	-0.695	-0.095	.002	<.001	3	3
BRCA	TRMT12 →	-0.428	-0.096	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000434 vs ATXN7L3B — LSCC

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