Regulation of protein neddylation

Across TCGA cell cohorts, RNA activity of the Regulation of protein neddylation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIA, ATP5IF1, and M6PR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPIA grouped by Regulation of protein neddylation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PPIA →	+0.711	+0.212	<.001	.001	3	5
CNS	ATP5IF1 →	-0.578	-0.174	.004	.001	3	5
LARGE_INTESTINE	M6PR →	+0.507	+0.141	<.001	.001	3	5
BLOOD_Leukemia	KBTBD2 →	+0.870	+0.178	.005	.003	3	4
OESOPHAGUS	SH2D5 →	+1.348	+0.135	.005	.003	3	4
OVARY	MAGOHB →	+0.664	+0.160	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPIA by Regulation of protein neddylation activity — KIDNEY

Explore this box plot interactively →