Regulation of protein neddylation

Across TCGA cell cohorts, RNA activity of the Regulation of protein neddylation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCUN1D4, UBXN7, and ZNF148, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein neddylation activity versus DCUN1D4 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DCUN1D4 →	+0.907	+0.076	<.001	<.001	3	15
LARGE_INTESTINE	UBXN7 →	+1.092	+0.098	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	ZNF148 →	+0.859	+0.112	.004	.004	3	13
UPPER_AERODIGESTIVE_TRACT	THAP6 →	+0.737	+0.085	.001	.001	2	14
BLOOD_Lymphoma	DCUN1D1 →	+0.924	+0.072	<.001	<.001	3	13
LARGE_INTESTINE	SMARCAD1 →	+0.887	+0.106	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000434 vs DCUN1D4 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →