Regulation of lamellipodium morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of lamellipodium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1C, HRH1, and FOSL1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lamellipodium morphogenesis activity versus CORO1C in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CORO1C →	+1.126	+0.636	<.001	.004	3	9
SOFT_TISSUE	HRH1 →	+2.076	+0.357	.003	.001	3	8
OVARY	FOSL1 →	+3.767	+0.821	<.001	.008	3	7
SOFT_TISSUE	CD44 →	+5.362	+0.389	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	FUT1 →	-0.798	-0.351	.008	.008	3	7
SOFT_TISSUE	SH2B3 →	+2.027	+0.326	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000392 vs CORO1C — BREAST

Explore this scatter interactively →